abstract：:Administration of certain drugs such as antidepressants have been shown to produce a phenomenon known as time-dependent sensitization, a process in which the acute effects of the drugs sensitize and grow over time. While both preclinical and clinical studies have demonstrated time-dependent sensitization, it is still ...

journal_title：Medical hypotheses

authors： Nathan P

更新日期：2000-06-01 00:00:00

abstract：:Excessive milk consumption may adversely affect the circulation on account of the high calcium content of milk and because lactose promotes the intestinal absorption of calcium. Excessive calcium intake may cause calcification and rigidification of the large elastic arteries, which could be an important factor in caus...

journal_title：Medical hypotheses

authors： Seely S

更新日期：2000-05-01 00:00:00

abstract：:Recent studies have shown that increased hepatic gluconeogenesis is the predominant contributor to fasting hyperglycemia - the hallmark of type 2 diabetes. Although it has been known for a long time that over-supply of fat is able to stimulate gluconeogenesis both in-vitro and in-vivo, neither the leading substrate no...

journal_title：Medical hypotheses

authors： Song S

更新日期：2000-05-01 00:00:00

abstract：:High-molecular-weight hyaluronic acid (HA) produced by the synovium may function physiologically to aid preservation of cartilage structure and prevent arthritic pain; both the size and concentration of HA in synovial fluid are diminished in osteoarthritis (OA). Glucosamine therapy for OA can be expected to increase s...

journal_title：Medical hypotheses

authors： McCarty MF,Russell AL,Seed MP

更新日期：2000-05-01 00:00:00

abstract：:As known, gamma-interferon-induced cell death in HeLa cells can be mediated via the recently identified protein kinase, death associated protein (DAP) kinase which is localized to the microfilament system of the cytoskeleton. However, the downstream or upstream effectors of DAP kinase remain uncertain. In the present ...

journal_title：Medical hypotheses

authors： Gerashchenko BI,Murata-Hori M,Hosoya H

更新日期：2000-05-01 00:00:00

abstract：:Reflux of biliary secretions into the pancreatic duct following gallstone obstruction of the common biliary pancreatic ampulla has been implicated as a cause of acute pancreatitis. However, the pancreatic duct pressure is higher than the biliary pressure and, therefore, the simple obstruction of the choledochoduodenal...

journal_title：Medical hypotheses

authors： Arendt T,Mönig H,Stüber E,Katsoulis S,Fölsch UR

更新日期：2000-04-01 00:00:00

abstract：:Styrene is one of the most important plastic monomers worldwide. Styrene-7,8-oxide (SO), the major in-vivo metabolite of styrene, is classified as probably carcinogenic to humans and carcinogenic in rodents. Biological monitoring of exposure to styrene is usually carried out by determination of mandelic acid and pheny...

journal_title：Medical hypotheses

authors： Marczynski B,Peel M,Baur X

更新日期：2000-04-01 00:00:00

abstract：:Several disorders or abnormalities observed in medicine and psychology are not explicable (or not fully explicable) by genetics and environmental influences, either alone or together. These include phobias and philias observed in early infancy, unusual play in childhood, homosexuality, gender identity disorder, a chil...

journal_title：Medical hypotheses

authors： Stevenson I

更新日期：2000-04-01 00:00:00

abstract：:A novel substance-attributed biophysical theory of brain-mind unity is presented. We separate spiritualism and matters of the soul from the medical sphere. Biophysical principles are responsible for the body's operational regimen (BOR) in the homeostatic state which allows for materialization and emergence of the mind...

journal_title：Medical hypotheses

authors： Naisberg Y

更新日期：2000-03-01 00:00:00

abstract：:The mechanism by which polyglutamine expansions in several proteins lead to neurodegenerative disorders remains largely unknown. The biochemical properties of polyglutamine repeats suggest one possible explanation; endolytic cleavage at a glutaminyl-glutaminyl bond followed by pyroglutamate formation may contribute to...

journal_title：Medical hypotheses

authors： Saido TC

更新日期：2000-03-01 00:00:00

abstract：:Epidemiological findings on the relation between foods and colon cancer are inconsistent. Many, but far from all, found positive associations for meat and fat and negative ones for vegetables and fruits. Explanations so far have focused on direct biochemical conversions in the colon or transit time, but they remain un...

journal_title：Medical hypotheses

authors： Holmqvist OH

更新日期：2000-03-01 00:00:00

abstract：:Synthetic and semisynthetic fabrics generate electrostatic potentials on the surface of the skin. The author suggests that the effects of electrostatic potentials on physical and psychological condition are mediated by acupuncture points. The author further suggests that electrostatic charges on the surface of the ski...

journal_title：Medical hypotheses

authors： Sher L

更新日期：2000-03-01 00:00:00

abstract：:The exact aetiology of mitral valve prolapse (MVP) is unknown, although this is the most common cardiac valvular abnormality currently detected. MVP has high incidence in young individuals, particularly during the second and third decades. These individuals are usually of a slender body habitus indicating higher rates...

journal_title：Medical hypotheses

authors： Kumar PD

更新日期：2000-02-01 00:00:00

abstract：:Cardiac chambers have afferent connections to the brainstem and to the spinal cord. Vagal afferents mediate depressor responses and become activated by volume expansion, increased myocardial contractility and atrial natriuretic factor. Sympathetic afferents, on the contrary, are activated by metabolic mediators, myoca...

journal_title：Medical hypotheses

authors： Davila DF,Donis JH,Bellabarba G,Torres A,Casado J,Mazzei de Davila C

更新日期：2000-02-01 00:00:00

abstract：:The paper proposes a mechanism for regulating nucleo-cytoplasmic exchanges of macromolecules via NPC in vertebrates. Bending of NE toward the transport vector significantly contributes to the dynamics. ...

journal_title：Medical hypotheses

authors： Matioli GT

更新日期：2000-01-01 00:00:00

abstract：:Some drugs blocking glutamate release produce reduced brain injury in some animal models of cerebral ischemia whereas others lack a clear effect. Meta-analysis is a widely used technique in clinical and epidemiological studies. However, it has never been used in the analysis of preclinical studies. In order to estimat...

journal_title：Medical hypotheses

authors： Nava-Ocampo AA,Reyes-Pérez H,Bello-Ramírez AM,Mansilla-Olivares A,Ponce-Monter H

更新日期：2000-01-01 00:00:00

abstract：:The etiologic basis of urinary tract anomalies and dysfunctional voiding largely remain unknown. However, the travel of urine from renal pelvis into the amniotic cavity under the pressures exerted by amniotic fluid satisfactorily explains the etiologic basis. Amniotic pressure is affected by the changes in maternal in...

journal_title：Medical hypotheses

authors： Tanyel FC

更新日期：2000-01-01 00:00:00

abstract：:Many experimental evidences indicate that infection with Trypanosoma cruzi delays or inhibits the growth of malignant tumors in different strains of mice and in rats. These facts were verified by different workers. Although earlier workers proposed that this effect would be due to a toxin of T. cruzi, most of the accu...

journal_title：Medical hypotheses

authors： Cabral HR

更新日期：2000-01-01 00:00:00

abstract：:Relapse to cocaine, heroin, and alcohol is a common occurrence in ex-abusers of these substances. Although there are many potential causes for relapse, we postulate that one cause in some people may be re-exposure in an anesthesia setting to a drug similar to the formerly abused drug. We hypothesize, for example, that...

journal_title：Medical hypotheses

authors： Sadeghi P,Zacny JP

更新日期：1999-12-01 00:00:00

abstract：:It is proposed that there is biological regulation of the low molecular weight antioxidant (LMWA) status of the body, and that these different antioxidants work in concert and in homeostasis as a system analogous to the regulation of acid-base status (pH). The theoretical design characteristics for such a system inclu...

journal_title：Medical hypotheses

authors： Berry EM,Kohen R

更新日期：1999-11-01 00:00:00

abstract：:Idiopathic intracranial hypertension (IHH or pseudotumor cerebri) is an uncommon but important cause of headache, characterized by raised intracranial pressure (ICP) in the absence of infection and intracranial pathology on neuroimaging. Lumbar puncture (LP) is usually contra-indicated in situations where the ICP is s...

journal_title：Medical hypotheses

authors： Salman M

更新日期：1999-10-01 00:00:00

abstract：:Howard Gardner identified five different kinds of creative activity among eminent creators, namely, solving a well-defined problem, putting forth a general conceptual scheme, creating a product that embodies ideas, stylized innovation of an art form, and a 'high-stakes' performance in the socio-political arena. In thi...

journal_title：Medical hypotheses

authors： Kantha SS

更新日期：1999-10-01 00:00:00

abstract：:The aim of the present paper is to give a schematic illustration of the basic humoral mechanisms of sodium, calcium and glucose homeostasis regulation. These can be compared to a lever system that maintains a dynamic equilibrium. ...

journal_title：Medical hypotheses

authors： Tolekova A,Popov B

更新日期：1999-09-01 00:00:00

abstract：:Recently, the metabolic routes for acetone metabolism have been described. Therefore, acetone cannot further be regarded as a waste product of metabolism. However, its physiological role in biochemical machinery is not clear. Here, an integrative model for the role of acetone metabolism is presented that orders the ev...

journal_title：Medical hypotheses

authors： Kalapos MP

更新日期：1999-09-01 00:00:00

abstract：:Cytokines and their effects are widely studied in immunology, but the cellular mechanisms responsible for producing these substances are not yet described or proven. Antigen presenting cells (APCs), macrophages and dendritic cells are suitable subjects for such a study. One of the many papers illustrating the interpla...

journal_title：Medical hypotheses

authors： Fedorko ME

更新日期：1999-08-01 00:00:00

abstract：:The etiology of drug-induced agranulocytosis is poorly understood. Many drugs that induce neutropenia or agranulocytosis can be metabolized to reactive intermediates that covalently bind to macromolecules. Until now, the myeloid precursor cell or an earlier committed progenitor cell has been favoured as the target for...

journal_title：Medical hypotheses

authors： Guest I,Uetrecht J

更新日期：1999-08-01 00:00:00

abstract：:The mechanism of pathogenesis of idiopathic Parkinson's disease (PD) is unknown. In a study of 200 PD patients and 200 age- and sex-matched controls, Strang noted a marked and statistically significant higher incidence of ulcers (diagnosed by X-ray or surgery) in the PD patients compared to the controls (14% to 4%). T...

journal_title：Medical hypotheses

authors： Altschuler E

更新日期：1999-07-01 00:00:00

abstract：:Since 1960, the incidence of melanoma has increased dramatically in Caucasians worldwide, and during the past decade has risen at a rate of 6% a year in the USA. A hypothesis regarding this increased incidence suggests that the prevalent use of antibacterial soaps that contain photosensitizing compounds may be a risk ...

journal_title：Medical hypotheses

authors： Arbesman H

更新日期：1999-07-01 00:00:00

abstract：:Carcinoma constitution originates in the hetero-duplication mitoses (4) which divide non-maturable stem cells into two different types of daughter cells: maturable and non-maturable cancerous stem cells. Throughout the progression of such mitoses, the organoid continuity of the cancer depends only on the non-maturable...

journal_title：Medical hypotheses

authors： Hirata Y

更新日期：1999-06-01 00:00:00

abstract：:Sudden infant death syndrome (SIDS) is frequently associated with a mild infection, the incidence peaking during the third month of life. We hypothesize that the neonatal immaturity of both the acute febrile response and hypothalamus promote neonatal protection from SIDS. Vagal afferents modify the febrile response. V...

journal_title：Medical hypotheses

authors： Reid GM,Tervit H

更新日期：1999-06-01 00:00:00

abstract：:Recent studies using a combination of isotope and balance techniques have shown that, in the postabsorptive state, the human kidney contributes substantially to overall glucose production and consumption. The kidney may contribute as much as the liver to gluconeogenesis and play an important role in the counterregulat...

journal_title：Medical hypotheses

authors： Stumvoll M,Meyer C,Mitrakou A,Gerich JE

更新日期：1999-05-01 00:00:00

abstract：:The incidence of insulin-dependent diabetes mellitus (IDDM), a chronic disease with a well-known genetic basis, is highest in Scandinavian and Sardinian populations. The high incidence of IDDM in Scandinavia and Sardinia, which were genetically isolated from the spread of agriculturists in Europe about 8000 years ago,...

journal_title：Medical hypotheses

authors： Wendorf MA

更新日期：1999-05-01 00:00:00

abstract：:In this review, tumor necrosis factor-alpha (TNF-alpha) is identified as the uniting principle linking the pathogenesis of insulin-dependent diabetes mellitus (IDDM), non-insulin dependent diabetes mellitus (NIDDM) and carcinoma. Elevated TNF-alpha initially increases, and then inhibits, the activity of a number of ke...

journal_title：Medical hypotheses

authors： Holden RJ,Pakula IS,Mooney PA

更新日期：1999-04-01 00:00:00

abstract：:The paradigm of an immune system presumes that a system arose specifically to combat infection -- hence its name. This paradigm gained credibility with the discovery of antibodies and anamnestic immunity, even though these are relatively late arrivals in evolution. Another presumption has been that thymus-dependent T ...

journal_title：Medical hypotheses

authors： Cunliffe J

更新日期：1999-03-01 00:00:00

abstract：:The authors hypothesize that the impairment of hypothalamic-pituitary-gonadal axis in patients suffering from anorexia nervosa depends (at least in part) on the increased sensitivity to endogenous melatonin. The hypothesis is based mainly on the following facts: (1) melatonin is well known to exert an inhibitory effec...

journal_title：Medical hypotheses

authors： Pawlikowski M,Zarzycki J

更新日期：1999-02-01 00:00:00

abstract：:The type of treatment that most psychiatric disturbances receive at present is a mixture of pharmacotherapy and psychotherapy, following the principle that mental functions are the result of the activities of brain machinery subsequent to the interaction between individuals and their external environment. We now know ...

journal_title：Medical hypotheses

authors： Galzigna L

更新日期：1999-01-01 00:00:00

abstract：:It is proposed that, in addition to genetic factors involved in immune attack on myelin, higher concentrations of nerve growth factor in certain tissues during development determine susceptibility to multiple sclerosis. High early nerve growth factor in some vasculature of spontaneously hypertensive rats increases sym...

journal_title：Medical hypotheses

authors： Olson RC

更新日期：1998-12-01 00:00:00

abstract：:The presence of the tumour induces important metabolic changes in the cancer patient which are not merely due to the fact that the tumour acts as a parasite, thus depleting the host of nutrients, but that are mainly the result of both tumoral and humoral mediators. The new metabolic status of the cancer patient may le...

journal_title：Medical hypotheses

authors： Argilés JM,López-Soriano FJ

更新日期：1998-11-01 00:00:00

abstract：:Articles dealing with the epidemiological aspects of asthma were carefully reviewed in order to support or reject our clinical impression of increased rate of asthma among immigrants. Particular emphasis was put on data on very high or very low rates of asthma. The proposed theories to explain these differences were c...

journal_title：Medical hypotheses

authors： Ballin A,Somekh E,Geva D,Meytes D

更新日期：1998-10-01 00:00:00

abstract：:In an effort to develop a method to ascertain whether ancient physicians used certain drugs because of their efficacy or for other reasons (random process, tradition, etc.), the authors have devised a statistical test (Efficacy Quotient-EQ) to evaluate ancient therapeutic data quantitatively. They have applied the Eff...

journal_title：Medical hypotheses

authors： Prioreschi P,Heaney RP,Brehm E

更新日期：1998-10-01 00:00:00